How Long Does It Take For Metformin To Work?
how long does it take for metformin to work In the UK it is common to use Metformin for gestational diabetes where dietary and lifestyle changes are not enough to lower and stabilise blood sugar levels. The team showed that metformin leads to the accumulation of AMP in mice, which inhibits an enzyme called adenylate cyclase, thereby reducing levels of cyclic AMP and protein kinase activity, eventually blocking glucagon-dependent glucose output from liver cells.
In response to continuous over-production of glucose by the liver, the pancreas secretes huge amounts of insulin to suppress it. This excess amount of insulin damages blood vessel walls34-36 and promotes tumor growth.37-41 For a type II diabetic who is over-producing insulin, the use of insulin injections provides a relatively brief respite from high blood glucose levels—with horrific long-term consequences.
Treatment with the OAM metformin reduced circulating insulin, LH, androstenedione, and testosterone concentrations in a number of studies, and protracted treatment has resulted in improvements in body mass index (BMI), menstrual cycle regulation, spontaneous ovulation rates, and spontaneous and assisted pregnancy rates ( 11 – 13 ). It has been hypothesized that by reducing circulating insulin concentrations, leading to decreased free androgen concentrations, OAMs may ameliorate hirsutism.
I was lucky enough to have a gynecologist that recoginized PCOS when I was a teen, but he didn’t do a damn thing to help me. I went to an Endo when I was in college and even though he should have been trained to deal with this he offered me no help either.